Effects of remdesivir on SARS-CoV-2 viral dynamics and mortality in viraemic patients hospitalized for COVID-19.

ABSTRACT:

Background

Studies on the antiviral effects of remdesivir have shown conflicting results. SARS-CoV-2 viraemia could identify patients in whom antiviral treatment may be particularly beneficial.

Objectives

To investigate antiviral effects and clinical outcomes of remdesivir treatment in viraemic patients.

Methods

Viraemic patients hospitalized for COVID-19 with ratio of arterial oxygen partial pressure to fractional inspired oxygen of ≤300, symptom duration ≤10 days, and estimated glomerular filtration rate ≥30 mL/min were included in a cohort. The rate of serum viral clearance and serum viral load decline, 60 day mortality and in-hospital outcomes were estimated. A subgroup analysis including patients with symptom duration ≤7 days was performed.

Results

A total

SUBMITTER: Hagman K 

PROVIDER: S-EPMC10631829 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature