Urine Quantification Following Furosemide for Severe Acute Kidney Injury Prediction in Critically Ill Children.

ABSTRACT: A standardized, quantified assessment of furosemide responsiveness predicts acute kidney injury (AKI) in children after cardiac surgery and AKI progression in critically ill adults. The purpose of this study was to determine if response to furosemide is predictive of severe AKI in critically ill children outside of cardiac surgery. We performed a multicenter retrospective study of critically ill children. Quantification of furosemide response was based on urine flow rate (normalized for weight) measurement 0 to 6 hours after the dose. The primary outcome was presence of creatinine defined severe AKI (Kidney Disease Improving Global Outcomes stage 2 or greater) within 7 days of furosemide administration. Secondary outcomes included mortality, duration of mechanical ventilation and length of

SUBMITTER: Gist KM 

PROVIDER: S-EPMC10631834 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature