Dataset Information

Algorithmic fairness in artificial intelligence for medicine and healthcare.

ABSTRACT: In healthcare, the development and deployment of insufficiently fair systems of artificial intelligence (AI) can undermine the delivery of equitable care. Assessments of AI models stratified across subpopulations have revealed inequalities in how patients are diagnosed, treated and billed. In this Perspective, we outline fairness in machine learning through the lens of healthcare, and discuss how algorithmic biases (in data acquisition, genetic variation and intra-observer labelling variability, in particular) arise in clinical workflows and the resulting healthcare disparities. We also review emerging technology for mitigating biases via disentanglement, federated learning and model explainability, and their role in the development of AI-based software as a medical device.

SUBMITTER: Chen RJ

PROVIDER: S-EPMC10632090 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Algorithmic fairness in artificial intelligence for medicine and healthcare.

Chen Richard J RJ Wang Judy J JJ Williamson Drew F K DFK Chen Tiffany Y TY Lipkova Jana J Lu Ming Y MY Sahai Sharifa S Mahmood Faisal F

Nature biomedical engineering 20230628 6

In healthcare, the development and deployment of insufficiently fair systems of artificial intelligence (AI) can undermine the delivery of equitable care. Assessments of AI models stratified across subpopulations have revealed inequalities in how patients are diagnosed, treated and billed. In this Perspective, we outline fairness in machine learning through the lens of healthcare, and discuss how algorithmic biases (in data acquisition, genetic variation and intra-observer labelling variability, ...[more]

PMID: 37380750

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Project description:ObjectivesStatistical and artificial intelligence algorithms are increasingly being developed for use in healthcare. These algorithms may reflect biases that magnify disparities in clinical care, and there is a growing need for understanding how algorithmic biases can be mitigated in pursuit of algorithmic fairness. We conducted a scoping review on algorithmic individual fairness (IF) to understand the current state of research in the metrics and methods developed to achieve IF and their applications in healthcare.Materials and methodsWe searched four databases: PubMed, ACM Digital Library, IEEE Xplore, and medRxiv for algorithmic IF metrics, algorithmic bias mitigation, and healthcare applications. Our search was restricted to articles published between January 2013 and November 2024. We identified 2498 articles through database searches and seven additional articles, of which 32 articles were included in the review. Data from the selected articles were extracted, and the findings were synthesized.ResultsBased on the 32 articles in the review, we identified several themes, including philosophical underpinnings of fairness, IF metrics, mitigation methods for achieving IF, implications of achieving IF on group fairness and vice versa, and applications of IF in healthcare.DiscussionWe find that research of IF is still in their early stages, particularly in healthcare, as evidenced by the limited number of relevant articles published between 2013 and 2024. While healthcare applications of IF remain sparse, growth has been steady in number of publications since 2012. The limitations of group fairness further emphasize the need for alternative approaches like IF. However, IF itself is not without challenges, including subjective definitions of similarity and potential bias encoding from data-driven methods. These findings, coupled with the limitations of the review process, underscore the need for more comprehensive research on the evolution of IF metrics and definitions to advance this promising field.ConclusionWhile significant work has been done on algorithmic IF in recent years, the definition, use, and study of IF remain in their infancy, especially in healthcare. Future research is needed to comprehensively apply and evaluate IF in healthcare.

Project description:Precision medicine is one of the recent and powerful developments in medical care, which has the potential to improve the traditional symptom-driven practice of medicine, allowing earlier interventions using advanced diagnostics and tailoring better and economically personalized treatments. Identifying the best pathway to personalized and population medicine involves the ability to analyze comprehensive patient information together with broader aspects to monitor and distinguish between sick and relatively healthy people, which will lead to a better understanding of biological indicators that can signal shifts in health. While the complexities of disease at the individual level have made it difficult to utilize healthcare information in clinical decision-making, some of the existing constraints have been greatly minimized by technological advancements. To implement effective precision medicine with enhanced ability to positively impact patient outcomes and provide real-time decision support, it is important to harness the power of electronic health records by integrating disparate data sources and discovering patient-specific patterns of disease progression. Useful analytic tools, technologies, databases, and approaches are required to augment networking and interoperability of clinical, laboratory and public health systems, as well as addressing ethical and social issues related to the privacy and protection of healthcare data with effective balance. Developing multifunctional machine learning platforms for clinical data extraction, aggregation, management and analysis can support clinicians by efficiently stratifying subjects to understand specific scenarios and optimize decision-making. Implementation of artificial intelligence in healthcare is a compelling vision that has the potential in leading to the significant improvements for achieving the goals of providing real-time, better personalized and population medicine at lower costs. In this study, we focused on analyzing and discussing various published artificial intelligence and machine learning solutions, approaches and perspectives, aiming to advance academic solutions in paving the way for a new data-centric era of discovery in healthcare.

Project description:Precision medicine has the potential to revolutionize the way cardiovascular diseases are diagnosed, predicted, and treated by tailoring treatment strategies to the individual characteristics of each patient. Artificial intelligence (AI) has recently emerged as a promising tool for improving the accuracy and efficiency of precision cardiovascular medicine. In this scoping review, we aimed to identify and summarize the current state of the literature on the use of AI in precision cardiovascular medicine. A comprehensive search of electronic databases, including Scopes, Google Scholar, and PubMed, was conducted to identify relevant studies. After applying inclusion and exclusion criteria, a total of 28 studies were included in the review. We found that AI is being increasingly applied in various areas of cardiovascular medicine, including the diagnosis, prognosis of cardiovascular diseases, risk prediction and stratification, and treatment planning. As a result, most of these studies focused on prediction (50%), followed by diagnosis (21%), phenotyping (14%), and risk stratification (14%). A variety of machine learning models were utilized in these studies, with logistic regression being the most used (36%), followed by random forest (32%), support vector machine (25%), and deep learning models such as neural networks (18%). Other models, such as hierarchical clustering (11%), Cox regression (11%), and natural language processing (4%), were also utilized. The data sources used in these studies included electronic health records (79%), imaging data (43%), and omics data (4%). We found that AI is being increasingly applied in various areas of cardiovascular medicine, including the diagnosis, prognosis of cardiovascular diseases, risk prediction and stratification, and treatment planning. The results of the review showed that AI has the potential to improve the performance of cardiovascular disease diagnosis and prognosis, as well as to identify individuals at high risk of developing cardiovascular diseases. However, further research is needed to fully evaluate the clinical utility and effectiveness of AI-based approaches in precision cardiovascular medicine. Overall, our review provided a comprehensive overview of the current state of knowledge in the field of AI-based methods for precision cardiovascular medicine and offered new insights for researchers interested in this research area.

Dataset Information

Algorithmic fairness in artificial intelligence for medicine and healthcare.

Publications

Algorithmic fairness in artificial intelligence for medicine and healthcare.

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