Glioma synapses recruit mechanisms of adaptive plasticity.

ABSTRACT: The role of the nervous system in the regulation of cancer is increasingly appreciated. In gliomas, neuronal activity drives tumour progression through paracrine signalling factors such as neuroligin-3 and brain-derived neurotrophic factor^1-3 (BDNF), and also through electrophysiologically functional neuron-to-glioma synapses mediated by AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors^4,5. The consequent glioma cell membrane depolarization drives tumour proliferation^4,6. In the healthy brain, activity-regulated secretion of BDNF promotes adaptive plasticity of synaptic connectivity^7,8 and strength^9-15. Here we show that malignant synapses exhibit similar plasticity regulated by BDNF. Signalling through the recepto

SUBMITTER: Taylor KR 

PROVIDER: S-EPMC10632140 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature