Neural signal propagation atlas of Caenorhabditis elegans.

ABSTRACT: Establishing how neural function emerges from network properties is a fundamental problem in neuroscience¹. Here, to better understand the relationship between the structure and the function of a nervous system, we systematically measure signal propagation in 23,433 pairs of neurons across the head of the nematode Caenorhabditis elegans by direct optogenetic activation and simultaneous whole-brain calcium imaging. We measure the sign (excitatory or inhibitory), strength, temporal properties and causal direction of signal propagation between these neurons to create a functional atlas. We find that signal propagation differs from model predictions that are based on anatomy. Using mutants, we show that extrasynaptic signalling not visible from anatomy contributes to this difference

SUBMITTER: Randi F 

PROVIDER: S-EPMC10632145 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature