Increased brain age and relationships with blood-based biomarkers following concussion in younger populations.

ABSTRACT:

Objective

Brain age is increasingly being applied to the spectrum of brain injury to define neuropathological changes in conjunction with blood-based biomarkers. However, data from the acute/sub-acute stages of concussion are lacking, especially among younger cohorts.

Methods

Predicted brain age differences were independently calculated in large, prospectively recruited cohorts of pediatric concussion and matched healthy controls (total N = 446), as well as collegiate athletes with sport-related concussion and matched non-contact sport controls (total N = 184). Effects of repetitive head injury (i.e., exposure) were examined in a separate cohort of contact sport athletes (N = 82), as well as by quantifying concussion history through semi-structured interviews and years of co

SUBMITTER: Mayer AR 

PROVIDER: S-EPMC10632216 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature