Domain-specific neuropsychological investigation of CAA with and without intracerebral haemorrhage.

ABSTRACT:

Background

Cerebral amyloid angiopathy (CAA) is associated with cognitive impairment, but the contributions of lobar intracerebral haemorrhage (ICH), underlying diffuse vasculopathy, and neurodegeneration, remain uncertain. We investigated the domain-specific neuropsychological profile of CAA with and without ICH, and their associations with structural neuroimaging features.

Methods

Data were collected from patients with possible or probable CAA attending a specialist outpatient clinic. Patients completed standardised neuropsychological assessment covering seven domains. MRI scans were scored for markers of cerebral small vessel disease and neurodegeneration. Patients were grouped into those with and without a macro-haemorrhage (CAA-ICH and CAA-non-ICH).

Results

We in

SUBMITTER: Chan E 

PROVIDER: S-EPMC10632296 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature