L-Palmitoylcarnitine potentiates plasmin and tPA to inhibit thrombosis.

ABSTRACT: L-Palmitoylcarnitine (L-PC) is an important endogenous fatty acid metabolite. Its classical biological functions are involved in the regulations of membrane molecular dynamics and the β-oxidation of fatty acids. Decreased plasma long-chain acylcarnitines showed the association of venous thrombosis, implying anticoagulant activity of the metabolites and inspiring us to investigate if and how L-PC, a long-chain acylcarnitine, takes part in coagulation. Here we show that L-PC exerted anti-coagulant effects by potentiating the enzymatic activities of plasmin and tissue plasminogen activator (tPA). L-PC directly interacts with plasmin and tPA with an equilibrium dissociation constant (KD) of 6.47 × 10^-9 and 4.46 × 10^-9 M, respectively, showing high affinities. In mouse mod

SUBMITTER: Yang J 

PROVIDER: S-EPMC10632336 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature