Identification of m6A-associated genes as prognostic and immune-associated biomarkers in Wilms tumor.

ABSTRACT:

Objectives

Wilms tumor (WT) is a common renal malignant tumor in children. We aimed to investigate the potential prognostic value of m6A-related genes and their relationship to the immune microenvironment in WT.

Methods

RNA-seq data and clinical information from 121 WT and 6 normal samples were obtained from the University of California Santa Cruz Xena database. We used various bioinformatics analysis tools to analyze these data and verify the expression level of m6A-related genes by experiments.

Results

Four m6A-related genes were successfully screened, including ADGRG2, CPD, CTHRC1, and LRTM2. Kaplan-Meier survival curves showed that the four genes were closely related to the prognosis of WT, which was also confirmed by receiver operator characteristic curves. Subse

SUBMITTER: Zhuo Y 

PROVIDER: S-EPMC10632345 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature