Ontology highlight
ABSTRACT:
SUBMITTER: Bicev RN
PROVIDER: S-EPMC10632367 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Bicev Renata Naporano RN de Souza Degenhardt Maximilia Frazão MF de Oliveira Cristiano Luis Pinto CLP da Silva Emerson Rodrigo ER Degrouard Jéril J Tresset Guillaume G Ronsein Graziella Eliza GE Demasi Marilene M da Cunha Fernanda Marques FM
Scientific reports 20231108 1
Caloric restriction is known to extend the lifespan and/or improve diverse physiological parameters in a vast array of organisms. In the yeast Saccharomyces cerevisiae, caloric restriction is performed by reducing the glucose concentration in the culture medium, a condition previously associated with increased chronological lifespan and 20S proteasome activity in cell extracts, which was not due to increased proteasome amounts in restricted cells. Herein, we sought to investigate the mechanisms ...[more]