Temporal chromatin accessibility changes define transcriptional states essential for osteosarcoma metastasis.

ABSTRACT: The metastasis-invasion cascade describes the series of steps required for a cancer cell to successfully spread from its primary tumor and ultimately grow within a secondary organ. Despite metastasis being a dynamic, multistep process, most omics studies to date have focused on comparing primary tumors to the metastatic deposits that define end-stage disease. This static approach means we lack information about the genomic and epigenomic changes that occur during the majority of tumor progression. One particularly understudied phase of tumor progression is metastatic colonization, during which cells must adapt to the new microenvironment of the secondary organ. Through temporal profiling of chromatin accessibility and gene expression in vivo, we identify dynamic changes in the epigenome th

SUBMITTER: Pontius WD 

PROVIDER: S-EPMC10632377 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature