IL6 suppresses vaccine responses in neonates by enhancing IL2 activity on T follicular helper cells.

ABSTRACT: The inability of neonates to develop CD4⁺FoxP3^-CXCR5^hiPD-1^hi T follicular helper (T_FH) cells contributes to their weak vaccine responses. In previous studies, we measured diminished IgG responses when IL-6 was co-injected with a pneumococcal conjugate vaccine (PCV) in neonatal mice. This is in sharp contrast to adults, where IL-6 improves vaccine responses by downregulating the expression of IL-2Rβ on T_FH cells and protecting them from the inhibitory effect of IL-2. In this study, we found that splenic IL-6 levels rapidly increased in both adult and neonatal mice following immunization, but the increase in neonatal mice was significantly more than that of adult mice. Moreover, immunized neonatal T_FH cells expresse

SUBMITTER: Parvathaneni S 

PROVIDER: S-EPMC10632457 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature