Inflammatory bowel disease biomarkers revealed by the human gut microbiome network.

ABSTRACT: Inflammatory bowel diseases (IBDs) are complex medical conditions in which the gut microbiota is attacked by the immune system of genetically predisposed subjects when exposed to yet unclear environmental factors. The complexity of this class of diseases makes them suitable to be represented and studied with network science. In this paper, the metagenomic data of control, Crohn's disease, and ulcerative colitis subjects' gut microbiota were investigated by representing this data as correlation networks and co-expression networks. We obtained correlation networks by calculating Pearson's correlation between gene expression across subjects. A percolation-based procedure was used to threshold and binarize the adjacency matrices. In contrast, co-expression networks involved the construction of

SUBMITTER: Hu M 

PROVIDER: S-EPMC10632483 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature