Effects of polydimethylsiloxane membrane surface treatments on human uterine smooth muscle cell strain response.

ABSTRACT: In the United States, 1 in 10 infants are born preterm. The majority of neonatal deaths and nearly a third of infant deaths are linked to preterm birth. Preterm birth is initiated when the quiescent state of the uterus ends prematurely, leading to contractions and parturition beginning as early as 32 weeks, though the origins are not well understood. To enable research and discovery of therapeutics with potential to better address preterm birth, the capability to study isolated cell processes of pregnant uterine tissue in vitro is needed. Our development of an in vitro model of the myometrium utilizing human uterine smooth muscle cells (uSMCs) responsible for contractions provides a methodology to examine cellular mechanisms of late-stage pregnancy potentially involved in pre

SUBMITTER: Marr EE 

PROVIDER: S-EPMC10632608 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature