Epigenetic aging differences between Wichi and Criollos from Argentina: Insights from genomic history and ecology.

ABSTRACT:

Background and objectives

Epigenetic estimators based on DNA methylation levels have emerged as promising biomarkers of human aging. These estimators exhibit natural variations across human groups, but data about indigenous populations remain underrepresented in research. This study aims to investigate differences in epigenetic estimators between two distinct human populations, both residing in the Gran Chaco region of Argentina, the Native-American Wichí, and admixed Criollos who are descendants of intermarriages between Native Americans and the first European colonizers, using a population genetic approach.

Methodology

We analyzed 24 Wichí (mean age: 39.2 ± 12.9 yo) and 24 Criollos (mean age: 41.1 ± 14.0 yo) for DNA methylation levels using the Infinium MethylationEPIC (Il

SUBMITTER: Iannuzzi V 

PROVIDER: S-EPMC10632719 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature