Long-term exposure to ambient PM2.5 and its constituents is associated with MAFLD.

ABSTRACT:

Background & aims

Existing evidence suggests that long-term exposure to ambient fine particulate pollution (PM_2.5) may increase metabolic dysfunction-associated fatty liver disease (MAFLD) risk. However, there is still limited evidence on the association of PM_2.5 constituents with MAFLD. Therefore, this study explores the associations between the five main chemical constituents of PM_2.5 and MAFLD to provide more explicit information on the liver exposome.

Methods

A total of 76,727 participants derived from the China Multi-Ethnic Cohort, a large-scale epidemic survey in southwest China, were included in this study. Multiple linear regression models were used to estimate the pollutant-specific association with MAFLD. Weighted quantile sum regre

SUBMITTER: Guo B 

PROVIDER: S-EPMC10632732 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature