CD138 promotes the accumulation and activation of autoreactive T cells in autoimmune MRL/lpr mice.

ABSTRACT: Autoreactive T cells, specifically CD138⁺ (syndecan-1) T cells produced in Fas-deficient systemic lupus erythematosus (SLE) mouse models, were shown to significantly promote the generation of autoantibodies. In the present study, Murphy Roths Large lymphoproliferative (MRL/lpr) lupus mice were used to investigate the role of CD138 protein expression in T cells in the progression of SLE. Measurement of flow cytometry, immunofluorescence and Luminex were performed to determine the effect of CD138 on T cells in MRL/lpr mice. The results demonstrate that CD138⁺ T cells induce apoptosis via a Fas-dependent pathway. CD138 protein expression in T cells of MRL/lpr mice significantly reduced T cell apoptosis and contributed to the accumulation of T cells and double negative (D

SUBMITTER: Xie T 

PROVIDER: S-EPMC10632966 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature