Effect of autologous lyophilized platelet‑rich fibrin on the reconstruction of osteochondral defects in rabbits.

ABSTRACT: Osteochondral defects caused by degenerative diseases of joints, traumas and inflammation are important issues in clinical practice. Different types of autologous platelet concentrate (PCs) are used in bone and cartilage regeneration. The present study aimed to investigate the effect of lyophilized platelet-rich fibrin (L-PRF) on the repair of osteochondral defects in rabbits. L-PRF was first prepared from fresh PRF (F-PRF) through freeze-drying, and histological and microstructural observations were performed to compare the characteristics of L-PRF and F-PRF. Thereafter, these bioactive scaffolds were implanted into osteochondral defects surgically created in rabbits to assess their effects on tissue repair using micro-CT scanning, histological observations and the evaluation scoring meth

SUBMITTER: Sun J 

PROVIDER: S-EPMC10632968 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature