Hydroxyapatite Incorporated with Fe3O4@MCM-41 Core-Shell: A Promising Nanocomposite for Teriparatide Delivery in Bone Tissue Regeneration.

ABSTRACT: This article presents a comprehensive study of the development of a novel nanocomposite comprising core-shell Fe3O4@MCM-41 with superparamagnetic properties and hydroxyapatite (HAp). The nanocomposite serves as a pH-responsive nanocarrier, offering an efficient injectable dosage for teriparatide (PTH (1-34)) delivery. The aim is to address the limitations associated with drug-induced side effects, precautionary measures, and frequent injections. The nanocomposites, as prepared, were characterized using techniques including X-ray diffraction, Fourier transform infrared, zeta potential, dynamic light scattering, VSM, scanning electron microscopy, and transmission electron microscopy. The nanocomposites' average crystallite diameter was determined to be 27 ± 5 nm. The hydrodynamic size of the

SUBMITTER: Hosseini HR 

PROVIDER: S-EPMC10633862 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature