Roles of gut microbiota in atrial fibrillation: insights from Mendelian randomization analysis and genetic data from over 430,000 cohort study participants.

ABSTRACT:

Background

Gut microbiota imbalances have been suggested as a contributing factor to atrial fibrillation (AF), but the causal relationship is not fully understood.

Objectives

To explore the causal relationships between the gut microbiota and AF using Mendelian randomization (MR) analysis.

Methods

Summary statistics were from genome-wide association studies (GWAS) of 207 gut microbial taxa (5 phyla, 10 classes, 13 orders, 26 families, 48 genera, and 105 species) (the Dutch Microbiome Project) and two large meta-GWASs of AF. The significant results were validated in FinnGen cohort and over 430,000 UK Biobank participants. Mediation MR analyses were conducted for AF risk factors, including type 2 diabetes, coronary artery disease (CAD), body mass index (BMI), blood lipid

SUBMITTER: Dai H 

PROVIDER: S-EPMC10633980 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature