Extracellular vesicles derived from endothelial cells modulate macrophage phenotype in vitro.

ABSTRACT: Extracellular vesicles (EVs) mediate cell-to-cell communication by horizontally transferring biological materials from host cells to target cells. During exposure to pathogens, pathogen-associated molecular patterns (e.g., lipopolysaccharide, LPS) get in contact with endothelial cells and stimulate the secretion of endothelial cell-derived EVs (E-EVs). The triggered EVs secretion is known to have a modulating influence on the EVs-receiving cells. Macrophages, a major component of innate immunity, are polarized upon receiving external inflammatory stimuli, in which toll-like receptor4 (TLR4)-nuclear factor kappa B (NFκB) pathway plays a key role. However, the functions of LPS-induced E-EVs (E_LPS-EVs) in modulating macrophage phenotype and activation remain elusive. We collected t

SUBMITTER: He Z 

PROVIDER: S-EPMC10634087 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature