Construction of miRNA-mRNA regulatory network indicates potential biomarkers for primary open-angle glaucoma.

ABSTRACT:

Background

Trabecular meshwork (TM) dysfunction-induced elevation of intraocular pressure has been identified as the main risk factor of irreversible optic nerve injury in Primary open‑angle glaucoma (POAG). Increasing evidences suggest that microRNA (miRNA) plays a vital role in the pathogenesis of POAG. This study aims to construct a miRNA-mRNA regulatory network and identify biomarkers for POAG.

Methods

miRNAs and mRNAs expression profiling of TM samples from controls and POAG patients were assessed through microarray analysis. Target genes of differentially expressed miRNAs (DEmiRNAs) were predicted by miEAA and miRNet. Then GO and KEGG pathway analysis of differentially expressed mRNAs (DEmRNAs) were performed. PPI of top 30 hub genes was identified and miRNA-mRNA netwo

SUBMITTER: Zhou X 

PROVIDER: S-EPMC10634160 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature