Regional sex differences in neurochemical profiles of healthy mice measured by magnetic resonance spectroscopy at 9.4 tesla.

ABSTRACT:

Objective

To determine sex differences in the neurochemical concentrations measured by in vivo proton magnetic resonance spectroscopy (¹H MRS) of healthy mice on a genetic background commonly used for neurodegenerative disease models.

Methods

¹H MRS data collected from wild type mice with C57BL/6 or related genetic backgrounds in seven prior studies were used in this retrospective analysis. To be included, data had to be collected at 9.4 tesla magnetic field using advanced ¹H MRS protocols, with isoflurane anesthesia and similar animal handling protocols, and a similar number of datasets from male and female mice had to be available for the brain regions analyzed. Overall, 155 spectra from female mice and 166 spectra from male mice (32

SUBMITTER: Tkac I 

PROVIDER: S-EPMC10634209 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature