Association between hepatitis B or hepatitis C virus infection and risk of pancreatic cancer: a systematic review and meta-analysis of cohort studies.

ABSTRACT:

Background and aim

With conflicting data from previous observational studies on the relationship between hepatitis B virus (HBV) or hepatitis C virus (HCV) infection and pancreatic cancer (PC), we decided to conduct a systematic review and meta-analysis in order to evaluate any potential association.

Design

This is a systematic review and meta-analysis.

Methods

We conducted a search of three databases (PubMed, Embase, and Web of Science) from the time of their creation up to June 2023. The summary results, including hazard ratio (HR) with 95% confidence interval (CI), were pooled using a generic inverse variance method and a random-effects model. Furthermore, subgroup and sensitivity analyses were conducted.

Results

In this meta-analysis, 22 cohort studies with

SUBMITTER: Zhao JF 

PROVIDER: S-EPMC10634262 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature