Inappropriate dosing of direct oral anticoagulants: findings from a clinical vignette study and physician survey.

ABSTRACT:

Objective

Direct oral anticoagulants (DOACs) are first-line therapy for stroke prevention for 1.4 million atrial fibrillation (AF) patients in the UK. However, the rates of DOAC dosing below evidence-based recommendations are estimated between 9% and 22%. This study explores specific patient and physician factors associated with prescribing inappropriate DOAC underdoses.

Methods

DOAC-prescribing physicians within the UK completed both a clinical vignette survey, which contained 12 hypothetical patient profiles designed to replicate DOAC prescribing scenarios, and a physician survey to capture sociodemographic, clinical experience, and prescriber-related beliefs and motivations related to DOAC prescribing. Eight patient factors based on a literature search and an expert consu

SUBMITTER: Fuat A 

PROVIDER: S-EPMC10634268 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature