Modular Approach for the Synthesis and Bioactivity Profiling of 8,8'-Biflavones.

ABSTRACT: In this work, we report the scalable and modular synthesis of a library of 55 monomeric and dimeric flavonoids including 14 8,8'-biflavones. The sterically demanding tetra-ortho-substituted axis of an acetophenone dimer key intermediate was constructed in a regioselective manner using Fe-mediated oxidative coupling. This step was systematically optimized and performed on up to multigram scale. The biological activities of this compound library were evaluated, including cytotoxicity against healthy and malignant human cell lines, antimicrobial activity against the apicomplexan parasite Toxoplasma gondii, and antioxidant capacity. A marked increase in activity for the 8,8'-dimeric structures compared to that of their monomeric counterparts was observed. Several biflavones were identified wit

SUBMITTER: Klischan MKT 

PROVIDER: S-EPMC10634270 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature