Development of a Structure for Lossless Ion Manipulations (SLIM) High Charge Capacity Array of Traps.

ABSTRACT: Enhancing the sensitivity of low-abundance ions in a complex mixture without sacrificing measurement throughput is highly desirable. This work demonstrates a way to greatly improve the sensitivity of ion mobility (IM)-selected ions by accumulating them in an array of high-capacity ion traps located inside a novel structures for lossless ion manipulations ion mobility spectrometer (SLIM-IMS) module. The array of ion traps used in this work consisted of seven independently controllable traps. Each trap was 386 mm long and possessed a charge capacity of ∼4.5 × 10⁸ charges, with a linear range extending to ∼2.5 × 10⁸ charges. Each ion trap could be used to extract a peak (or ions over a mobility range) from an ion mobility separation based on arrival time. Ions could be s

SUBMITTER: Huntley AP 

PROVIDER: S-EPMC10634340 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature