Effect of Traveling Waveform Profiles on Collision Cross Section Measurements in Structures for Lossless Ion Manipulations.

ABSTRACT: We evaluated the effect of four different waveform profiles (Square, Sine, Triangle, and asymmetric Sawtooth) on the accuracy of collision cross section (CCS) measurements using traveling wave ion mobility spectrometry (TWIMS) separations in structures for lossless ion manipulations (SLIM). The effects of the waveform profiles on the accuracy of the CCS measurements were evaluated for four classes of compounds (lipids, peptides, steroids, and nucleosides) at different TW speeds (126-206 m/s) and amplitudes (15-89 V). For the lipids and peptides, the TWIMS-based CCS (^TWCCS) deviations from the corresponding drift-tube-based CCS (^DTCCS) measurements were significantly lower in experiments conducted using the Sawtooth waveform compared to the square waveform. This observ

SUBMITTER: Kwantwi-Barima P 

PROVIDER: S-EPMC10634343 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature