Worldwide emergence of fluconazole-resistant Candida parapsilosis: current framework and future research roadmap.

ABSTRACT: Candida parapsilosis is one of the most commen causes of life-threatening candidaemia, particularly in premature neonates, individuals with cancer of the haematopoietic system, and recipients of organ transplants. Historically, drug-susceptible strains have been linked to clonal outbreaks. However, worldwide studies started since 2018 have reported severe outbreaks among adults caused by fluconazole-resistant strains. Outbreaks caused by fluconazole-resistant strains are associated with high mortality rates and can persist despite strict infection control strategies. The emergence of resistance threatens the efficacy of azoles, which is the most widely used class of antifungals and the only available oral treatment option for candidaemia. The fact that most patients infected with fluconazo

SUBMITTER: Daneshnia F 

PROVIDER: S-EPMC10634418 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature