Calcium sulfate-Cu²⁺ delivery system improves 3D-Printed calcium silicate artificial bone to repair large bone defects.

ABSTRACT: There are still limitations in artificial bone materials used in clinical practice, such as difficulty in repairing large bone defects, the mismatch between the degradation rate and tissue growth, difficulty in vascularization, an inability to address bone defects of various shapes, and risk of infection. To solve these problems, our group designed stereolithography (SLA) 3D-printed calcium silicate artificial bone improved by a calcium sulfate-Cu²⁺ delivery system. SLA technology endows the scaffold with a three-dimensional tunnel structure to induce cell migration to the center of the bone defect. The calcium sulfate-Cu²⁺ delivery system was introduced to enhance the osteogenic activity of calcium silicate. Rapid degradation of calcium sulfate (CS) induces early ost

SUBMITTER: Gao S 

PROVIDER: S-EPMC10634439 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature