Molecular basis of the phenotypic variants arising from a Pseudoalteromonas lipolytica mutator.

ABSTRACT: Bacterial deficiencies in the DNA repair system can produce mutator strains that promote adaptive microevolution. However, the role of mutator strains in marine Pseudoalteromonas, capable of generating various gain-of-function genetic variants within biofilms, remains largely unknown. In this study, inactivation of mutS in Pseudoalteromonas lipolytica conferred an approximately 100-fold increased resistance to various antibiotics, including ciprofloxacin, rifampicin and aminoglycoside. Furthermore, the mutator of P. lipolytica generated variants that displayed enhanced biofilm formation but reduced swimming motility, indicating a high phenotypic diversity within the ΔmutS population. Additionally, we observed a significant production rate of approximately

SUBMITTER: Zeng Z 

PROVIDER: S-EPMC10634453 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature