Association of Atrial Fibrillation With Stroke and Dementia Accounting for Left Atrial Function and Size.

ABSTRACT:

Background

Atrial fibrillation (AF) is associated with higher risks of ischemic stroke (IS) and dementia. Whether alterations in left atrial (LA) function or size-atrial myopathy-confound these associations remains unknown.

Objectives

The purpose of this study was to examine the association of prevalent and incident AF with ischemic stroke and dementia in the ARIC (Atherosclerosis Risk In Communities) study, adjusting for LA function and size.

Methods

Participants at visit 5 (2011-2013) with echocardiographic LA function (reservoir, conduit, contractile strain, and emptying fraction) and size (maximal, minimal volume index) data, and without prevalent stroke or dementia were followed through 2019. For analysis, we used time-varying Cox regression.

Results

Among

SUBMITTER: Zhang MJ 

PROVIDER: S-EPMC10634508 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature