Intracranial electrical stimulation of corticolimbic sites modulates arousal in humans.

ABSTRACT:

Background

Humans routinely shift their sleepiness and wakefulness levels in response to emotional factors. The diversity of emotional factors that modulates sleep-wake levels suggests that the ascending arousal network may be intimately linked with networks that mediate mood. Indeed, while animal studies have identified select limbic structures that play a role in sleep-wake regulation, the breadth of corticolimbic structures that directly modulates arousal in humans remains unknown.

Objective

We investigated whether select regional activation of the corticolimbic network through direct electrical stimulation can modulate sleep-wake levels in humans, as measured by subjective experience and behavior.

Methods

We performed intensive inpatient stimulation mapping in two

SUBMITTER: Fan JM 

PROVIDER: S-EPMC10634663 | biostudies-literature | 2023 Jul-Aug

REPOSITORIES: biostudies-literature