Assembly of Protein Complexes In and On the Membrane with Predicted Spatial Arrangement Constraints.

ABSTRACT: Membrane proteins play crucial roles in various cellular processes, and their interactions with other proteins in and on the membrane are essential for their proper functioning. While an increasing number of structures of more membrane proteins are being determined, the available structure data is still sparse. To gain insights into the mechanisms of membrane protein complexes, computational docking methods are necessary due to the challenge of experimental determination. Here, we introduce Mem-LZerD, a rigid-body membrane docking algorithm designed to take advantage of modern membrane modeling and protein docking techniques to facilitate the docking of membrane protein complexes. Mem-LZerD is based on the LZerD protein docking algorithm, which has been constantly among the top servers in

SUBMITTER: Christoffer C 

PROVIDER: S-EPMC10634698 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature