Sex and species associated differences in Complement-mediated immunity in Humans and Rhesus macaques.

ABSTRACT: The complement system can be viewed as a 'moderator' of innate immunity, 'instructor' of humoral immunity, and 'regulator' of adaptive immunity. While sex and aging are known to affect humoral and cellular immune systems, their impact on the complement pathway in humans and rhesus macaques, a commonly used non-human primate model system, have not been well-studied. To address this knowledge gap, we analyzed serum samples from 90 humans and 75 rhesus macaques for the abundance and activity of the complement system components. While sequences of cascade proteins were highly conserved, dramatically different levels were observed between species. Whereas the low levels detected in rhesus samples raised questions about the suitability of the test, differences in levels of complement proteins we

SUBMITTER: Kelkar NS 

PROVIDER: S-EPMC10634758 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature