Gene expression analyses reveal differences in children's response to malaria according to their age.

ABSTRACT: In Bandiagara, Mali, children experience on average two clinical malaria episodes per season. However, even in the same transmission area, the number of uncomplicated symptomatic infections, and their parasitemia, vary dramatically among children. To examine the factors contributing to these variations, we simultaneously characterized the host and parasite gene expression profiles from 136 children with symptomatic falciparum malaria and analyzed the expression of 9,205 human and 2,484 Plasmodium genes. We used gene expression deconvolution to estimate the relative proportion of immune cells and parasite stages in each sample and to adjust the differential gene expression analyses. Parasitemia explained much of the variation in both host and parasite gene expression and revealed tha

SUBMITTER: Tebben K 

PROVIDER: S-EPMC10634788 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature