Breast Cancer Macrophage Heterogeneity and Self-renewal are Determined by Spatial Localization.

ABSTRACT: Tumor-infiltrating macrophages support critical steps in tumor progression, and their accumulation in the tumor microenvironment (TME) is associated with adverse outcomes and therapeutic resistance across human cancers. In the TME, macrophages adopt diverse phenotypic alterations, giving rise to heterogeneous immune activation states and induction of cell cycle. While the transcriptional profiles of these activation states are well-annotated across human cancers, the underlying signals that regulate macrophage heterogeneity and accumulation remain incompletely understood. Here, we leveraged a novel ex vivo organotypic TME (oTME) model of breast cancer, in vivo murine models, and human samples to map the determinants of functional heterogeneity of TME macrophages. We identifie

SUBMITTER: Ben-Chetrit N 

PROVIDER: S-EPMC10634790 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature