Modeling the dynamics of actin and myosin during bleb stabilization.

ABSTRACT: The actin cortex is very dynamic during migration of eukaryotes. In cells that use blebs as leading-edge protrusions, the cortex reforms beneath the cell membrane (bleb cortex) and completely disassembles at the site of bleb initiation. Remnants of the actin cortex at the site of bleb nucleation are referred to as the actin scar. We refer to the combined process of cortex reformation along with the degradation of the actin scar during bleb-based cell migration as bleb stabilization. The molecular factors that regulate the dynamic reorganization of the cortex are not fully understood. Myosin motor protein activity has been shown to be necessary for blebbing, with its major role associated with pressure generation to drive bleb expansion. Here, we examine the role of myosin in regulat

SUBMITTER: Asante-Asamani E 

PROVIDER: S-EPMC10634845 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature