RpoS activates formation of Salmonella Typhi biofilms and drives persistence in the gall bladder.

ABSTRACT: The development of strategies for targeting the asymptomatic carriage of Salmonella Typhi in chronic typhoid patients has suffered owing to our basic lack of understanding of the molecular mechanisms that enable the formation of S. Typhi biofilms. Traditionally, studies have relied on cholesterol-attached biofilms formed by a closely related serovar, Typhimurium, to mimic multicellular Typhi communities formed on human gallstones. In long-term infections, S. Typhi adopts the biofilm lifestyle to persist in vivo and survive in the carrier state, ultimately leading to the spread of infections via the fecal-oral route of transmission. In the present work, we studied S. Typhi biofilms directly, applied targeted as well as genome-wide genetic approaches to uncover un

SUBMITTER: Desai SK 

PROVIDER: S-EPMC10634867 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature