Plexin-B1 and Plexin-B2 play non-redundant roles in GABAergic synapse formation.

ABSTRACT: Synapse formation in the mammalian brain is a complex and dynamic process requiring coordinated function of dozens of molecular families such as cell adhesion molecules (CAMs) and ligand-receptor pairs (Ephs/Ephrins, Neuroligins/Neurexins, Semaphorins/Plexins). Due to the large number of molecular players and possible functional redundancies within gene families, it is challenging to determine the precise synaptogenic roles of individual molecules, which is key to understanding the consequences of mutations in these genes for brain function. Furthermore, few molecules are known to exclusively regulate either GABAergic or glutamatergic synapses, and cell and molecular mechanisms underlying GABAergic synapse formation in particular are not thoroughly understood. However, we previously demons

SUBMITTER: Adel SS 

PROVIDER: S-EPMC10634878 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature