Dataset Information

A polydiolcitrate-MoS₂ composite for 3D printing Radio-opaque, Bioresorbable Vascular Scaffolds.

ABSTRACT: Implantable polymeric biodegradable devices, such as biodegradable vascular stents or scaffolds, cannot be fully visualized using standard X-ray-based techniques, compromising their performance due to malposition after deployment. To address this challenge, we describe composites of methacrylated poly(1,12 dodecamethylene citrate) (mPDC) and MoS₂ nanosheets to fabricate novel X-ray visible radiopaque and photocurable liquid polymer-ceramic composite (mPDC-MoS₂). The composite was used as an ink with micro continuous liquid interface production (μCLIP) to fabricate bioresorbable vascular scaffolds (BVS). Prints exhibited excellent crimping and expansion mechanics without strut failures and, importantly, required X-ray visibility in air and muscle tissue. Notably, MoS₂ nanosheets displayed physical degradation over time in a PBS environment, indicating the potential for producing bioresorbable devices. mPDC-MoS₂ is a promising bioresorbable X-ray-visible composite material suitable for 3D printing medical devices, particularly vascular scaffolds or stents, that require non-invasive X-ray-based monitoring techniques for implantation and evaluation. This innovative composite system holds significant promise for the development of biocompatible and highly visible medical implants, potentially enhancing patient outcomes and reducing medical complications.

SUBMITTER: Szydlowska BM

PROVIDER: S-EPMC10634906 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Publications

A polydiolcitrate-MoS2 composite for 3D printing Radio-opaque, Bioresorbable Vascular Scaffolds.

Szydlowska Beata M BM Ding Yonghui Y Moore Connor C Cai Zizhen Z Torres-Castanedo Carlos G CG Jones Evan E Hersam Mark C MC Sun Cheng C Ameer Guillermo A GA

bioRxiv : the preprint server for biology 20231101

Implantable polymeric biodegradable devices, such as biodegradable vascular stents or scaffolds, cannot be fully visualized using standard X-ray-based techniques, compromising their performance due to malposition after deployment. To address this challenge, we describe composites of methacrylated poly(1,12 dodecamethylene citrate) (mPDC) and MoS2 nanosheets to fabricate novel X-ray visible radiopaque and photocurable liquid polymer-ceramic composite (mPDC-MoS2). The composi ...[more]

PMID: 37961681

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Project description:With recent developments in materials engineering and additive manufacturing, the feasibility of patient-specific biomedical devices has increased substantially. Bioresorbable vascular stents/scaffolds (BVS), implants which reopen narrowed blood vessels, have seen considerable research in freeform fabrication as one such potentially customizable medical device. However, clinical requirements for stents place significant limits on manufacturing; the device must maintain the vessel's natural diameter once it has been reopened and must have sub-100 μm radial thickness to allow proper blood flow in small diameter vessels. Recent commercialization challenges for BVSs have highlighted the importance of meeting these requirements. For example, the first BVS marketed in the U.S.A., made from polylactide, had a radial thickness of 150 μm, which potentially contributed to negative side-effects and reduced efficacy. Thus, new bioresorbable materials and manufacturing strategies are required to fabricate BVSs that have sub-100 μm feature sizes that are mechanically competent and safe. In this work, we report the innovative use of a two-phase system that enables in situ formation of semicrystalline poly-l-lactic acid nanofibrous networks within a 3D printed polymeric matrix of a bioresorbable citrate-based biomaterial used for the first time in a resorbable medical device recently approved by the Food and Drug Administration. The optimized composite ink is compatible with the high-resolution micro-continuous liquid interphase production method with demonstrated smallest printable features of 80 μm. The resulting composite material has a significantly improved Young's modulus of 969.55 MPa at the fully hydrated state, a 108% improvement over the previously reported pure citrate-based biomaterial materials. We have successfully fabricated the BVS with strut thicknesses less than 100 μm and demonstrated that the stent can sustain applied vessel loading under physiological blood pressure conditions. The fabrication method can potentially be broadly applied to other biomedical devices.

Dataset Information

A polydiolcitrate-MoS₂ composite for 3D printing Radio-opaque, Bioresorbable Vascular Scaffolds.

Publications

A polydiolcitrate-MoS<sub>2</sub> composite for 3D printing Radio-opaque, Bioresorbable Vascular Scaffolds.

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