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Multi-echo Acquisition and Thermal Denoising Advances Infant Precision Functional Imaging.

ABSTRACT: The characterization of individual functional brain organization with Precision Functional Mapping has provided important insights in recent years in adults. However, little is known about the ontogeny of inter-individual differences in brain functional organization during human development, but precise characterization of systems organization during periods of high plasticity might be most influential towards discoveries promoting lifelong health. Collecting and analyzing precision fMRI data during early development has unique challenges and emphasizes the importance of novel methods to improve data acquisition, processing, and analysis strategies in infant samples. Here, we investigate the applicability of two such methods from adult MRI research, multi-echo (ME) data acquisition and thermal noise removal with Noise reduction with distribution corrected principal component analysis (NORDIC), in precision fMRI data from three newborn infants. Compared to an adult example subject, T2* relaxation times calculated from ME data in infants were longer and more variable across the brain, pointing towards ME acquisition being a promising tool for optimizing developmental fMRI. The application of thermal denoising via NORDIC increased tSNR and the overall strength of functional connections as well as the split-half reliability of functional connectivity matrices in infant ME data. While our findings related to NORDIC denoising are coherent with the adult literature and ME data acquisition showed high promise, its application in developmental samples needs further investigation. The present work reveals gaps in our understanding of the best techniques for developmental brain imaging and highlights the need for further developmentally-specific methodological advances and optimizations, towards precision functional imaging in infants.

SUBMITTER: Moser J

PROVIDER: S-EPMC10634909 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Multi-echo Acquisition and Thermal Denoising Advances Precision Functional Imaging.

Moser Julia J Nelson Steven M SM Koirala Sanju S Madison Thomas J TJ Labonte Alyssa K AK Carrasco Cristian Morales CM Feczko Eric E Moore Lucille A LA Lundquist Jacob T JT Weldon Kimberly B KB Grimsrud Gracie G Hufnagle Kristina K Ahmed Weli W Myers Michael J MJ Adeyemo Babatunde B Snyder Abraham Z AZ Gordon Evan M EM Dosenbach Nico U F NUF Tervo-Clemmens Brenden B Larsen Bart B Moeller Steen S Yacoub Essa E Vizioli Luca L Uğurbil Kamil K Laumann Timothy O TO Sylvester Chad M CM Fair Damien A DA

bioRxiv : the preprint server for biology 20241009

The characterization of individual functional brain organization with Precision Functional Mapping has provided important insights in recent years in adults. However, little is known about the ontogeny of inter-individual differences in brain functional organization during human development. Precise characterization of systems organization during periods of high plasticity is likely to be essential for discoveries promoting lifelong health. Obtaining precision fMRI data during development has un ...[more]

PMID: 37961636

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Dataset Information

Multi-echo Acquisition and Thermal Denoising Advances Infant Precision Functional Imaging.

Publications

Multi-echo Acquisition and Thermal Denoising Advances Precision Functional Imaging.

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