MetaGate: Interactive Analysis of High-Dimensional Cytometry Data with Meta Data Integration.

ABSTRACT: Flow cytometry is a powerful technology for high-throughput protein quantification at the single-cell level, widely used in basic research and routine clinical diagnostics. Traditionally, data analysis is carried out using manual gating, in which cut-offs are defined manually for each marker. Recent technical advances, including the introduction of mass cytometry, have increased the number of proteins that can be simultaneously assessed in each cell. To tackle the resulting escalation in data complexity, numerous new analysis algorithms have been developed. However, many of these show limitations in terms of providing statistical testing, data sharing, cross-experiment comparability integration with clinical data. We developed MetaGate as a platform for interactive statistical analysis and

SUBMITTER: Ask EH 

PROVIDER: S-EPMC10634916 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature