dms-viz: Structure-informed visualizations for deep mutational scanning and other mutation-based datasets.

ABSTRACT: Understanding how mutations impact a protein's functions is valuable for many types of biological questions. High-throughput techniques such as deep-mutational scanning (DMS) have greatly expanded the number of mutation-function datasets. For instance, DMS has been used to determine how mutations to viral proteins affect antibody escape (Dadonaite et al. 2023), receptor affinity (Starr et al. 2020), and essential functions such as viral genome transcription and replication (Li et al. 2023). With the growth of sequence databases, in some cases the effects of mutations can also be inferred from phylogenies of natural sequences (Bloom and Neher 2023) (Figure 1). The mutation-based data generated by these approaches is often best understood in the context of a protein's 3D structure; for insta

SUBMITTER: Hannon WW 

PROVIDER: S-EPMC10634933 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature