Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer disease.

ABSTRACT: Hub regions in the brain, recognized for their roles in ensuring efficient information transfer, are vulnerable to pathological alterations in neurodegenerative conditions, including Alzheimer Disease (AD). Given their essential role in neural communication, disruptions to these hubs have profound implications for overall brain network integrity and functionality. Hub disruption, or targeted impairment of functional connectivity at the hubs, is recognized in AD patients. Computational models paired with evidence from animal experiments hint at a mechanistic explanation, suggesting that these hubs may be preferentially targeted in neurodegeneration, due to their high neuronal activity levels-a phenomenon termed "activity-dependent degeneration". Yet, two critical issues were unresolved. Fir

SUBMITTER: Tu JC 

PROVIDER: S-EPMC10634945 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature