Interdependence of cellular and network properties in respiratory rhythmogenesis.

ABSTRACT: How breathing is generated by the preBötzinger Complex (preBötC) remains divided between two ideological frameworks, and the persistent sodium current (I_NaP) lies at the heart of this debate. Although I_NaP is widely expressed, the pacemaker hypothesis considers it essential because it endows a small subset of neurons with intrinsic bursting or "pacemaker" activity. In contrast, burstlet theory considers I_NaP dispensable because rhythm emerges from "pre-inspiratory" spiking activity driven by feed-forward network interactions. Using computational modeling, we discover that changes in spike shape can dissociate I_NaP from intrinsic bursting. Consistent with many experimental benchmarks, conditional effects o

SUBMITTER: Phillips RS 

PROVIDER: S-EPMC10634953 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature