NREM sleep oscillations and their relations with sleep-dependent memory consolidation in early course psychosis and first-degree relatives.

ABSTRACT: Sleep spindles are believed to mediate sleep-dependent memory consolidation, particularly when coupled to neocortical slow oscillations. Schizophrenia is characterized by a deficit in sleep spindles that correlates with reduced overnight memory consolidation. Here, we examined sleep spindle activity, slow oscillation-spindle coupling, and both motor procedural and verbal declarative memory consolidation in early course, minimally medicated psychosis patients and non-psychotic first-degree relatives. Using a four-night experimental procedure, we observed significant deficits in spindle density and amplitude in patients relative to controls that were driven by individuals with schizophrenia. Schizophrenia patients also showed reduced sleep-dependent consolidation of motor procedural memory,

SUBMITTER: Denis D 

PROVIDER: S-EPMC10634996 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature