Stability of DNA-Methylation Profiles of Biological Aging in Children and Adolescents.

ABSTRACT:

Background and objectives

Methylation profile scores (MPSs) index biological aging and aging-related disease in adults and are cross-sectionally associated with social determinants of health in childhood. MPSs thus provide an opportunity to trace how aging-related biology responds to environmental changes in early life. Information regarding the stability of MPSs in early life is currently lacking.

Method

We use longitudinal data from children and adolescents ages 8-18 (N = 428, M age = 12.15 years) from the Texas Twin Project. Participants contributed two waves of salivary DNA-methylation data (mean lag = 3.94 years), which were used to construct four MPSs reflecting multi-system physiological decline and mortality risk (PhenoAgeAccel and GrimAgeAccel), pace of biological a

SUBMITTER: deSteiguer AJ 

PROVIDER: S-EPMC10635005 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature