Systems profiling reveals recurrently dysregulated cytokine signaling responses in ER+ breast cancer patients' blood.

ABSTRACT: Cytokines mediate cell-to-cell communication across the immune system and therefore are critical to immunosurveillance in cancer and other diseases. Several cytokines show dysregulated abundance or signaling responses in breast cancer, associated with the disease and differences in survival and progression. Cytokines operate in a coordinated manner to affect immune surveillance and regulate one another, necessitating a systems approach for a complete picture of this dysregulation. Here, we profiled cytokine signaling responses of peripheral immune cells from breast cancer patients as compared to healthy controls in a multidimensional manner across ligands, cell populations, and responsive pathways. We find alterations in cytokine responsiveness across pathways and cell types that are best

SUBMITTER: Orcutt-Jahns B 

PROVIDER: S-EPMC10635026 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature