Molecular subtypes of high-grade serous ovarian cancer across racial groups and gene expression platforms.

ABSTRACT:

Introduction

High-grade serous carcinoma (HGSC) gene expression subtypes are associated with differential survival. We characterized HGSC gene expression in Black individuals and considered whether gene expression differences by race may contribute to poorer HGSC survival among Black versus non-Hispanic White individuals.

Methods

We included newly generated RNA-Seq data from Black and White individuals, and array-based genotyping data from four existing studies of White and Japanese individuals. We assigned subtypes using K-means clustering. Cluster- and dataset-specific gene expression patterns were summarized by moderated t-scores. We compared cluster-specific gene expression patterns across datasets by calculating the correlation between the summarized vectors of moderate

SUBMITTER: Davidson NR 

PROVIDER: S-EPMC10635053 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature